Önyükleyiciyi Kapat

LONG TERM SIDE EFFECTS

(months - years after transplant)

Chronic Graft Versus Host Disease (KGVHH) is a common side effect in allogenic transplants; Immune system cells (graft) from the donor attack the body of the transplant patient (host). Chronic GVHD, whose symptoms and time of occurrence differs from acute GVHD, is sometimes similar to autoimmune diseases. The entire body, especially the skin, eyes, joints and digestive system, can be affected. It can range from mild to life threatening seriousness.

Thyroid problems. Some transplant patients who have undergone whole body irradiation may have hypothyroidism (underworking of the thyroid) or other thyroid problems. Symptoms of hypothyroidism are weakness, weight gain and depression.

Secondary cancer risk. Chemotherapy and radiation therapy increase the likelihood that a person will encounter another cancer later. There is an even higher risk for those who receive whole body radiation or experience chronic GVHD.

Cataracts (deterioration in the lens of the eye) can develop 3-4 years after transplantation.

Late effects in children. Transplant can affect growth and development in children: learning disability, skeletal growth, growth hormone deficiency, late adolescence, infertility and other problems.

Additional information on risks, side effects and treatment can be found at marrow.org/patient


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